The task of the embryology core will be to: To facilitate the further characterization of homologous recombination mutations and transgene expression, the Embryology Core will continue to provide high quality in situ hybridizations of mouse embryos and sections. (1) Analyze the expression pattern of genes affected by homologous recombination knockouts and transgene expression in mouse embryos and in particular in the embryonic cardiovascular system. This involves analysis by in situ hybridization on tissue sections and on whole-mounts. (2) Train investigators in the techniques of gene expression analysis. To assist investigators in documenting their results for the purpose of data analysis and publication.